A safe and effective glycine dosage has not yet been established. Therefore, it is probably a good idea to follow the dosing guidelines on the label of your particular glycine product. If you find that you are not seeing the benefits you expected, you may want to slightly increase the dose. If you experience any side effects, try decreasing the glycine dose.
Glycine is an amino acid that is sometimes used in dietary supplements. It is important to note that unlike medications (for which the standard doses have been well established), there is less information available for determining the best dose for supplements, including glycine.
Because there is not enough reliable evidence to guide you in your choice of a glycine dosage, a good plan is to start with a reasonable dose (such as the recommended starting dose on the label of your glycine product, or perhaps a little less) and see how your body reacts to that dose. If it seems to be working a little, but not quite well enough, perhaps a higher dose (but not more than recommended on the label) would be right for you. If you find that you are experiencing glycine side effects, perhaps a lower dose would be better. A maximum glycine dose that is both safe and effective has not been established.
In studies, a typical glycine dosage for treating schizophrenia was based on body weight -- 400 mg to 800 mg per kg (about 180 mg to 360 mg per pound) daily, split into smaller doses. However, this is much more than most glycine supplements recommend (and is expensive and impractical, as it would require the use of many glycine capsules or quite of bit of glycine powder for each dose).
Some considerations for people taking glycine include:
- Because the manufacturing of supplements (such as glycine) is not closely regulated, it is important to choose a trustworthy manufacturer for glycine supplements. It is a good idea to look for the "USP" symbol, as this means that the supplement has been tested and contains the right ingredients in the right amounts.
- If you have any chronic health problems or take any prescription medications, it is probably a good idea to check with your healthcare provider before taking glycine.
- If you are unsure about anything related to your dosage or glycine dosing in general, please talk with your healthcare provider.