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Glycine Drug Interactions
When certain medications are taken with glycine, drug interactions can occur. Specifically, if glycine is combined with atypical antipsychotics (such as aripiprazole, clozapine, or olanzapine), it may decrease the effectiveness of these medications. To prevent these and other interactions, do not combine these medications with glycine without your healthcare provider's approval and supervision.
Even though glycine is a natural product, it can potentially interact with some medicines. Some of these medicines that may lead to glycine drug interactions include:
- Aripiprazole (Abilify®)
- Clozapine (Clozaril®)
- Olanzapine (Zyprexa®)
- Paliperidone (Invega®)
- Quetiapine (Seroquel®)
- Risperidone (Risperdal®)
- Ziprasidone (Geodon®).
All of the medications listed in this article are classified as atypical antipsychotics. Although glycine is sometimes claimed to be useful for treating schizophrenia, one study showed that adding glycine supplementation to clozapine seemed to decrease the effectiveness of clozapine for schizophrenia treatment. It is assumed that this could also happen with other, similar atypical antipsychotic medications (such as the ones listed in this article). Do not combine glycine supplements with any of these medications without the approval and supervision of your healthcare provider.
It is possible that not every drug interaction with glycine was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the glycine interactions that may apply to your specific situation.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD