Safety of Glycine

People who have schizophrenia or certain allergies may not be able to take glycine. Safety precautions also apply to women who are pregnant or breastfeeding. To help minimize potential risks, make sure to look for a reputable manufacturer of glycine that abides by the rules of GMP for drugs and to check the label of the glycine product for the USP seal.

Is Glycine Safe?

Glycine is a dietary supplement that is used to treat a variety of conditions. However, you may not be able to take glycine safely if you:
  • Have schizophrenia
  • Have any allergies, including allergies to foods, dyes, or preservatives
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Glycine Warnings and Precautions

Some of the warnings and precautions to be aware of concerning the safety of glycine include the following:
  • Although glycine is sometimes claimed to be useful for schizophrenia treatment, one study showed that combining glycine with certain schizophrenia medications could actually make the medications less effective (see Glycine Drug Interactions). If you have schizophrenia, do not take glycine without your healthcare provider's approval.
  • It is not known if glycine supplements are safe for pregnant or breastfeeding women (see Glycine and Pregnancy and Glycine and Breastfeeding).
  • If you decide to use supplements (such as glycine), what you see on the label may not reflect what is in the bottle. For example, some herbal supplements have been found to be contaminated with heavy metals or prescription drugs, and some have been found to have much more or much less of the featured ingredient than their label states. 
Therefore, make sure the manufacturer of your glycine product is a trusted and reputable manufacturer. It is a good sign if a manufacturer abides by the rules of Good Manufacturing Practices (GMP) for drugs. It is also a good sign if a product has the United States Pharmacopoeia (USP) seal, which means that the product has been independently tested and shown to contain the correct ingredients in the amounts listed on the label. Your pharmacist is a good resource for information about which manufacturers are the most reputable.
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Glycine Supplement Information

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