Plavix Drug Interactions

For people taking Plavix, drug interactions may be a concern. Plavix can interact with a number of different medications. For instance, taking Plavix and warfarin together may increase the risk of bleeding, as can taking nonsteroidal anti-inflammatory drugs (NSAIDs) with Plavix. Herbal and nutritional supplements can also interfere with Plavix and possibly increase the risk of bleeding.

An Introduction to Interactions With Plavix

Plavix® (clopidogrel bisulfate) has a number of medicines that it can potentially interact with. Some of these Plavix drug interactions involve medications such as:
 
 
  • Fluvastatin (Lescol®)  
  • Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs) or otherwise increase bleeding risk, such as:
     
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
Several herbal and nutritional supplements can also interact with Plavix and may increase the risk of bleeding. Examples of these include but are not limited to:
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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